THE SYNTHESIS AND BIOCHEMICAL EVALUATION OF NEW A(1) SELECTIVE ADENOSINE RECEPTOR AGONISTS CONTAINING 6-HYDRAZINOPURINE MOIETIES

The synthesis and SAR of a series of novel derivatives of N-aminoadeno sine is described, along with their in vitro effects in biochemical as says. The rat brain A1 adenosine receptor binding of these compounds i s very dependent upon the purine 2-substituent. The novel agonist, -ch loro-N-[4-(phenylthio)-1-piperidinyl]adenosine, exhibits a K(i) value for A1 receptor binding of <1 nM.