SYNTHESIS AND BRONCHOSPASMOLYTIC PROPERTIES OF SOME PYRIDAZINONE DERIVATIVES

Authors
CORSANO S STRAPPAGHETTI G SCAPICCHI R SCALISE O
Citation
S. Corsano et al., SYNTHESIS AND BRONCHOSPASMOLYTIC PROPERTIES OF SOME PYRIDAZINONE DERIVATIVES, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2713-2716
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2713 - 2716
Database
ISI
SICI code
0960-894X(1993)3:12<2713:SABPOS>2.0.ZU;2-L
Abstract
The synthesis and evaluation of the biological activity of a series of 3(2H)-pyridazinones is reported. The bronchodilating activity of thes e compounds was determined on the guinea pig trachea. Compounds 6 and 17 with 1-(4-amino-3,5-dichlorophenyl)-2-hydroxyethyl-and 1-(3,4-dichl orophenyl)-2-hydroxyethyl groups linked through a piperazine ring to t he 6-position of 3(2H)-pyridazinone show a good bronchospasmolytic act ivity.