A GENERAL-APPROACH TOWARD THE DESIGN OF MECHANISM-BASED INACTIVATORS OF SERINE PROTEINASES - INACTIVATION OF HUMAN-LEUKOCYTE ELASTASE BY A PHTHALIMIDE DERIVATIVE

Authors
GROUTAS WC CHONG LS VENKATARAMAN R HUANG H EPP JB KUANG RZ
Citation
Wc. Groutas et al., A GENERAL-APPROACH TOWARD THE DESIGN OF MECHANISM-BASED INACTIVATORS OF SERINE PROTEINASES - INACTIVATION OF HUMAN-LEUKOCYTE ELASTASE BY A PHTHALIMIDE DERIVATIVE, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2745-2750
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2745 - 2750
Database
ISI
SICI code
0960-894X(1993)3:12<2745:AGTTDO>2.0.ZU;2-3
Abstract
A general approach toward the design of mechanism-based inhibitors of serine proteinases involving the linking of fragment -CHX-COOR to an a ppropriate recognition element is described.