INTRODUCTION OF A LIPOPHILIC THIOETHER TETHER IN THE MINOR-GROOVE OF NUCLEIC-ACIDS FOR ANTISENSE APPLICATIONS

Authors
MANOHARAN M JOHNSON LK TIVEL KL SPRINGER RH COOK PD
Citation
M. Manoharan et al., INTRODUCTION OF A LIPOPHILIC THIOETHER TETHER IN THE MINOR-GROOVE OF NUCLEIC-ACIDS FOR ANTISENSE APPLICATIONS, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2765-2770
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2765 - 2770
Database
ISI
SICI code
0960-894X(1993)3:12<2765:IOALTT>2.0.ZU;2-E
Abstract
A 2'-O-hexylthiotrityl adenosine phosphoramidite has been synthesized and incorporated into oligonucleotide phosphodiesters and phosphorothi oates. This tether has potential antisense applications, offers a conv enient nucleophile for conjugation of various moieties that would resi de in the minor groove, and may form novel tertiary structures.