SYNTHESIS AND EXCITATORY AMINO-ACID PHARMACOLOGY OF SOME NOVEL QUINOXALINEDIONES

Authors
EPPERSON JR HEWAWASAM P MEANWELL NA BOISSARD CG GRIBKOFF VK POSTMUNSON D
Citation
Jr. Epperson et al., SYNTHESIS AND EXCITATORY AMINO-ACID PHARMACOLOGY OF SOME NOVEL QUINOXALINEDIONES, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2801-2804
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2801 - 2804
Database
ISI
SICI code
0960-894X(1993)3:12<2801:SAEAPO>2.0.ZU;2-4
Abstract
The synthesis and amino acid pharmacology of twelve N-substituted quin oxalinediones is reported. In particular, compounds 4a and 4b show sig nificant antagonism at both the AMPA and glycine-site NMDA receptors. The functional antagonism of 4a has been demonstrated.