N-2 METHYLATED QUATERNARY DERIVATIVES OF BETA-CARBOLINE-3-CARBOXYLATES INHIBIT ACETYLCHOLINESTERASE IN-VITRO

Authors
DEKHANE M DUBOIS L BLANCHET G GARRIGUE H SENTENACROUMANOU H POTIER P DODD RH
Citation
M. Dekhane et al., N-2 METHYLATED QUATERNARY DERIVATIVES OF BETA-CARBOLINE-3-CARBOXYLATES INHIBIT ACETYLCHOLINESTERASE IN-VITRO, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2831-2836
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2831 - 2836
Database
ISI
SICI code
0960-894X(1993)3:12<2831:NMQDOB>2.0.ZU;2-K
Abstract
Alkyl beta-carboline-3-carboxylate derivatives (e.g. beta-CCM and beta -CCB), known to interact with the central benzodiazepine receptor, wer e quaternized at the N-2 position using methyl iodide. The products st rongly inhibited acetylcholinesterase in vitro and displayed affinitie s for muscarinic receptors in the micromolar range.