STRUCTURE-DIRECTED DISCOVERY OF AN INHIBITOR OF THE BINDING OF HIV GP120 TO THE CD4 RECEPTOR

Authors
JARVEST RL BREEN AL EDGE CM CHAIKIN MA JENNINGS LJ TRUNEH A SWEET RW HERTZBERG RP
Citation
Rl. Jarvest et al., STRUCTURE-DIRECTED DISCOVERY OF AN INHIBITOR OF THE BINDING OF HIV GP120 TO THE CD4 RECEPTOR, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2851-2856
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2851 - 2856
Database
ISI
SICI code
0960-894X(1993)3:12<2851:SDOAIO>2.0.ZU;2-E
Abstract
Structure-directed screening identified the diphenyl lactone (1) as a specific inhibitor of the interaction of HIV gp120 with CD4. The compo und bound selectively to gp120 in a time-dependent and irreversible fa shion.