SYNTHESIS AND CHARACTERIZATION OF N-AMINO-GLYPHOSPHATE AS A POTENT ANALOG INHIBITOR OF ESCHERICHIA-COLI EPSP SYNTHASE

Authors
KNOWLES WS ANDERSON KS ANDREW SS PHILLION DP REAM JE JOHNSON KA SIKORSKI JA
Citation
Ws. Knowles et al., SYNTHESIS AND CHARACTERIZATION OF N-AMINO-GLYPHOSPHATE AS A POTENT ANALOG INHIBITOR OF ESCHERICHIA-COLI EPSP SYNTHASE, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2863-2868
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2863 - 2868
Database
ISI
SICI code
0960-894X(1993)3:12<2863:SACONA>2.0.ZU;2-P
Abstract
All previous attempts to identify glyphosate analogs which retain thei r potency against the known biological target, EPSP synthase, have bee n unsuccessful. Consequently, the glyphosate binding site was thought to be extremely specific in this system. Here we report the novel N-am ino glyphosate analog 3 as the first successful modification of the gl yphosate skeleton which exhibits inhibitor properties comparable to gl yphosate.