Ws. Knowles et al., SYNTHESIS AND CHARACTERIZATION OF N-AMINO-GLYPHOSPHATE AS A POTENT ANALOG INHIBITOR OF ESCHERICHIA-COLI EPSP SYNTHASE, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2863-2868
All previous attempts to identify glyphosate analogs which retain thei
r potency against the known biological target, EPSP synthase, have bee
n unsuccessful. Consequently, the glyphosate binding site was thought
to be extremely specific in this system. Here we report the novel N-am
ino glyphosate analog 3 as the first successful modification of the gl
yphosate skeleton which exhibits inhibitor properties comparable to gl
yphosate.