INHIBITION OF CARTILAGE BREAKDOWN BY ISOTHIAZOLONES

Authors
WRIGHT SW PETRAITIS JJ ABELMAN MM BOSTROM LL CORBETT RL GREEN AM KINDT RM SHERK SR MAGOLDA RL
Citation
Sw. Wright et al., INHIBITION OF CARTILAGE BREAKDOWN BY ISOTHIAZOLONES, Bioorganic & medicinal chemistry letters, 3(12), 1993, pp. 2875-2878
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
12
Year of publication
1993
Pages
2875 - 2878
Database
ISI
SICI code
0960-894X(1993)3:12<2875:IOCBBI>2.0.ZU;2-F
Abstract
Isothiazolones and isoselenazolones have been found to inhibit IL-1bet a induced breakdown of bovine nasal cartilage in an organ culture assa y. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, non-peptide lead series approach t o the mediation of the chronic cartilage breakdown associated with art hritic disease.