PROTECTIVE EFFECTS OF TAIWAN CRUDE DRUGS ON EXPERIMENTAL LIVER INJURIES

Protective effects of 41 Taiwan crude drugs on rat hepatic injuries ca used by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate ( ANIT) were investigated. The methanol extracts of Elephantopi Herba an d Lonicerae Flos inhibited the release of intrahepatic enzymes and his tological changes by CCl4. The methanol extracts of Canarii Radix, Are cae Pericarpium, Cynomorii Caulis, Polygoni Cuspidati Radix, Phyllodii Herba, Junci Caulis Medulla, Rubiae Herba and Rhinacanthi Herba prote cted the hepatic injury by ANIT. Among them, the water extracts of Cym orii Caulis and Junci Caulis Medulla showed higher protective potency than the methanol extracts. And them this two crude drugs also protect ed the cholestasis by ANIT.