SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NK(1) TACHYKININ ANTAGONISTS NOTCONTAINING D-RESIDUES

Authors
POULOS C ANTONIOU M PATACCHINI R MAGGI CA ROVERO P
Citation
C. Poulos et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NK(1) TACHYKININ ANTAGONISTS NOTCONTAINING D-RESIDUES, Neuropeptides, 26(1), 1994, pp. 55-57
Citations number
9
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
26
Issue
1
Year of publication
1994
Pages
55 - 57
Database
ISI
SICI code
0143-4179(1994)26:1<55:SABONT>2.0.ZU;2-2
Abstract
A series of analogues of the previously reported NK1 tachykinin antago nist [Orn6, Glu(OBzl)11]-SP6-11-OBzl has been synthesized and tested i n order to investigate the effects on antagonistic activity of modific ations at the C-terminal residue. The biological activity in the guine a-pig ileum assay (NK1 receptor) indicates that the two aromatic rings introduced in the C-terminal part of the peptide are both essential f or the expression of antagonistic activity.