AROMATIC AND AZAAROMATIC DISELENIDES, BENZISOSELENAZOLONES AND RELATED-COMPOUNDS AS IMMUNOMODULATORS ACTIVE IN HUMANS - SYNTHESIS AND PROPERTIES

Convenient syntheses of aryl diselenides 2, 1,2-benzisoselenazol-3(2H) -ones 4 and their 1-oxides 7 are reported. Reductive conversions of th ese compounds to bis(2-carbamoyl)-phenyl diselenides 5 and oxidative c yclization of 5 to 1,2-benzisoselenazol-3(2H)-one 1-oxides 7 as the me thods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN-gamma, in human peripheral b lood leucocyte cultures is described.