BETA-CARBOLINE ALKALOIDS .4. SYNTHESES OF 1-ALKYL-BETA-CARBOLINES ANDSTRUCTURE REVISION OF LYCII ALKALOID-I

Authors
BRACHER F HILDEBRAND D
Citation
F. Bracher et D. Hildebrand, BETA-CARBOLINE ALKALOIDS .4. SYNTHESES OF 1-ALKYL-BETA-CARBOLINES ANDSTRUCTURE REVISION OF LYCII ALKALOID-I, Liebigs Annalen der Chemie, (12), 1993, pp. 1335-1337
Citations number
29
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen der Chemie → ACNP
ISSN journal
01702041
Issue
12
Year of publication
1993
Pages
1335 - 1337
Database
ISI
SICI code
0170-2041(1993):12<1335:BA.SO1>2.0.ZU;2-W
Abstract
Palladium-catalyzed coupling reactions of 1-chloro-beta-carboline (1) with triethylborane and trimethylaluminum give the alkaloids 1-ethyl-b eta-carboline (2) and harman (5). The intermediate 4 on treatment with ethyl formiate gives 9-formylharman (6). Comparison of the spectrosco pic data shows, that lycii alkaloid I does not have the structure 6, b ut is identical with the alkaloid 1-acetyl-beta-carboline (7).