TREATMENT OF KLEBSIELLA-PNEUMONIAE SEPTICEMIA IN NORMAL AND LEUKOPENIC MICE BY LIPOSOME-ENCAPSULATED MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMIDE

The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae s epticemia resulting from intraperitoneal bacterial inoculation was inv estigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPP E) or 40% (LE-MTPPE), whereas untreated control mice died. Only repeat ed prophylactic treatment with LE-MTPPE could further increase surviva l up to 85%.