During October 1992 an increase in the number of isolates of Salmonell
a mikawasima, a rare serotype, was noted including a cluster of nine c
ases in the South West Thames region. A case control study was conduct
ed and univariate analysis showed a statistical association between il
lness and eating at takeaway A for cases compared with household contr
ols (P = 0.003) and with neighbourhood controls (P = 0.0245). Cases we
re also more likely to have eaten kebabs than were controls or average
takeaway A customers, implicating doner kebabs as the most likely veh
icle of infection. Plasmid profile analysis of the nine cases' isolate
s showed them to be indistinguishable and to be characterized by a sin
gle plasmid of approximately 60 MDa. The original source of the Salmon
ella mikawasima contamination was not determined, but food preparation
practices for kebabs at takeaway A were insufficient to protect again
st illness if contaminated. This outbreak was only recognized because
of the unusual serotype, but could be an indication of a more widespre
ad problem with doner kebabs.