COWDENS-DISEASE WITH EXTENSIVE GASTROINTESTINAL POLYPOSIS

Cowden's disease, or multiple hamartoma syndrome, is a rare condition classified recently as a hereditary preneoplastic syndrome. Multiple o rocutaneous hamartomas are associated with involvement of other organ systems, including fibrocystic breast disease and breast carcinoma, go iter, thyroid cancer, gastrointestinal polyps, and endometrial carcino ma. We describe a patient with Cowden's disease who underwent extensiv e gastroenterological work-up and review other cases in the literature .