OOCYTE DONATION - COMPARISON BETWEEN RECIPIENTS FROM DIFFERENT AGE-GROUPS

Citation
C. Flamigni et al., OOCYTE DONATION - COMPARISON BETWEEN RECIPIENTS FROM DIFFERENT AGE-GROUPS, Human reproduction, 8(12), 1993, pp. 2088-2092
Citations number
23
Categorie Soggetti
Reproductive Biology
Journal title
ISSN journal
02681161
Volume
8
Issue
12
Year of publication
1993
Pages
2088 - 2092
Database
ISI
SICI code
0268-1161(1993)8:12<2088:OD-CBR>2.0.ZU;2-Z
Abstract
Oocyte donation was carried out in 87 patients in 141 replacement cycl es. These patients received oocytes from 108 women undergoing assisted reproductive technology procedures at our centre. Standardized hormon al replacement therapy and in-vitro fertilization procedures were perf ormed. We divided recipients into four groups according to their age ( group A, 21-35 years; B, 36 - 40 years; C, 41-49 years; and D, 50-61 y ears). Oocytes donors were 21-35 years old, and equally spread across these different age groups. There were significant differences in the pregnancy and implantation rates according to the age of the recipient s; which were 45% and 23% respectively in women 21-35 years old (group A) versus 23% and 10% in women 41-49 years old (group C). A compariso n of data between oocyte donors and their specific recipients showed s imilar results in donors and young recipients, with pregnancy rates of 45% and 42% and implantation rates of 23% and 19.5% respectively. Sta tistically significant differences were found between donors and the o lder recipients, pregnancy rates being 43% versus 23%, and implantatio n rates 18% versus 10%. These data seem to demonstrate a lesser likeli hood of pregnancy and implantation in older recipients because of incr easing uterine age.