ACQUIRED HEMOPHILIA IN ASSOCIATION WITH TYPE-III VON WILLEBRANDS DISEASE - SUCCESSFUL TREATMENT WITH HIGH-PURITY VON WILLEBRANDS FACTOR ANDRECOMBINANT FACTOR VIIA

A patient with autosomal dominant (Type III) von Willebrand's disease (vWd) developed acquired haemophilia post-operatively, possibly due to exposure to amoxycillin. She refused porcine factor VIII (pFVIII) on religious grounds and was managed successfully with recombinant activa ted factor VII (rFVIIa) together with highly purified von Willebrand f actor concentrate (vWf-VHP). In patients with acquired haemophilia rFV IIa appears to be a suitable agent for symptomatic management.