A FACILE SYNTHESIS OF SODIUM 3-[1-C-14]-ETHYL-7-ISOPROPYL-1-AZULENESULFONATE

Authors
SHIMADA T YANAGISAWA T TOMIYAMA T OKAZAKI M
Citation
T. Shimada et al., A FACILE SYNTHESIS OF SODIUM 3-[1-C-14]-ETHYL-7-ISOPROPYL-1-AZULENESULFONATE, Journal of labelled compounds & radiopharmaceuticals, 34(1), 1994, pp. 79-83
Citations number
8
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
1
Year of publication
1994
Pages
79 - 83
Database
ISI
SICI code
0362-4803(1994)34:1<79:AFSOS3>2.0.ZU;2-G
Abstract
Sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1, a new therapeutic age nt for stomatitis, pharyngitis and ophthalmia was labelled with carbon -14 in the ethyl group attached to the azulene ring for use in metabol ic studies. C-14-labelled 1 with a specific activity of 1.98 GBq/mmol was prepared in four steps in 39.3 % overall chemical yield from [1-C- 14]acetic acid sodium salt.