A GENERAL PROCEDURE FOR ISOTOPIC (DEUTERIUM) LABELING OF NONSTEROIDALANTIINFLAMMATORY 2-ARYLPROPIONIC ACIDS

Authors
CASTELL JV MARTINEZ LA MIRANDA MA TARREGA P
Citation
Jv. Castell et al., A GENERAL PROCEDURE FOR ISOTOPIC (DEUTERIUM) LABELING OF NONSTEROIDALANTIINFLAMMATORY 2-ARYLPROPIONIC ACIDS, Journal of labelled compounds & radiopharmaceuticals, 34(1), 1994, pp. 93-100
Citations number
12
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
1
Year of publication
1994
Pages
93 - 100
Database
ISI
SICI code
0362-4803(1994)34:1<93:AGPFI(>2.0.ZU;2-S
Abstract
Alkaline treatment of nonsteroidal antiinflammatory 2-arylpropionic ac ids in deuterium oxide led in all cases to isotopic exchange of the pr oton located at the alpha-position of the side chain. Monodeuteration was observed in the case of carprofen, ibuprofen, ketoprofen, fenoprof en, flurbiprofen and naproxen. Additional exchange of one or two proto ns of the heterocyclic ring occurred in indoprofen, suprofen and tiapr ofenic acid. The isotopic labelling survived under the conditions requ ired to perform in vitro photoallergic studies (photolysis in non-deut erated aqueous media).