A small neutrino Majorana mass can arise in the Standard Model as an e
ffective dimension 5 operator. We calculate the renormalization of thi
s operator in the minimal Standard Model and in its two-Higgs-doublet
and supersymmetric extensions. Renormalization from the scale of lepto
n number violation (e.g., the Planck scale or a GUT scale) to the weak
scale decreases the strength of this operator by an order of magnitud
e or more if the top quark and Higgs boson masses are large. Neutrino
mixing angles also run with momentum. We show instances where small mi
xing at a high scale becomes large at the weak scale, and vice versa.