PHARMACOKINETICS OF ALFENTANIL IN PATIENTS TREATED WITH EITHER CIMETIDINE OR RANITIDINE

Citation
J. Kienlen et al., PHARMACOKINETICS OF ALFENTANIL IN PATIENTS TREATED WITH EITHER CIMETIDINE OR RANITIDINE, Drug investigation, 6(5), 1993, pp. 257-262
Citations number
NO
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
01142402
Volume
6
Issue
5
Year of publication
1993
Pages
257 - 262
Database
ISI
SICI code
0114-2402(1993)6:5<257:POAIPT>2.0.ZU;2-M
Abstract
The pharmacokinetics of alfentanil were studied after single dose intr avenous administration of 125 mug/kg to 19 intensive care unit patient s who were divided into 3 groups. Group I was given oral antacid, and groups II and III were given, respectively, cimetidine 1200 mg/day IV and ranitidine 300 mg/day IV for 48 hours before administration of alf entanil. Alfentanil plasma concentrations were determined over the 8 h ours following drug administration using a radio immunoassay. Pharmaco kinetic parameters were calculated using a noncompartmental analysis. In group II, alfentanil plasma concentrations were significantly highe r than in the other groups. In addition, significant changes involving the elimination half-life (142.3 +/- 35 vs 81.14 +/- 11 and 88.1 +/- 33 minutes), total clearance (1.27 +/- 0.5 vs 3.56 +/- 1.17 and 2.74 /- 1 ml/kg/min) and total volume of distribution related to the pseudo distribution phase (226 +/- 73 vs 336 +/- 76 and 271 +/- 61 ml/kg) we re found in group II vs groups I and III. These results suggest that p retreatment with cimetidine alters alfentanil pharmacokinetics after s ingle dose administration. In contrast, ranitidine does not appear to have a significant effect.