R. Bright et al., 5-BROMOBARBITURIC ACID - A MILD AND SELECTIVE MONOBROMINATING AGENT EMPLOYED IN THE SYNTHESIS OF THE GASTRIN ANTAGONIST GR174152, Synthetic communications, 26(22), 1996, pp. 4195-4209
5-Bromobarbituric acid (5) is a convenient reagent for the selective b
romination of cyclic imine 3. A facile, in situ synthesis of this reag
ent involving a disproportionation reaction between barbituric acid an
d dibromobarbituric acid is described.