5-BROMOBARBITURIC ACID - A MILD AND SELECTIVE MONOBROMINATING AGENT EMPLOYED IN THE SYNTHESIS OF THE GASTRIN ANTAGONIST GR174152

Authors
BRIGHT R COOTE SJ FREEMAN S HAYES D SMITH G TAPOLCZAY D
Citation
R. Bright et al., 5-BROMOBARBITURIC ACID - A MILD AND SELECTIVE MONOBROMINATING AGENT EMPLOYED IN THE SYNTHESIS OF THE GASTRIN ANTAGONIST GR174152, Synthetic communications, 26(22), 1996, pp. 4195-4209
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
22
Year of publication
1996
Pages
4195 - 4209
Database
ISI
SICI code
0039-7911(1996)26:22<4195:5A-AMA>2.0.ZU;2-M
Abstract
5-Bromobarbituric acid (5) is a convenient reagent for the selective b romination of cyclic imine 3. A facile, in situ synthesis of this reag ent involving a disproportionation reaction between barbituric acid an d dibromobarbituric acid is described.