ANGIOTENSIN-CONVERTING ENZYME IN RENAL ONTOGENY - HYPOTHESIS FOR MULTIPLE ROLES

Authors
JUNG FF BOUYOUNES B BARRIO R TANG SS DIAMANT D INGELFINGER JR
Citation
Ff. Jung et al., ANGIOTENSIN-CONVERTING ENZYME IN RENAL ONTOGENY - HYPOTHESIS FOR MULTIPLE ROLES, Pediatric nephrology, 7(6), 1993, pp. 834-840
Citations number
NO
Categorie Soggetti
Pediatrics,"Urology & Nephrology
Journal title
Pediatric nephrology
ISSN journal
0931041X → ACNP
Volume
7
Issue
6
Year of publication
1993
Pages
834 - 840
Database
ISI
SICI code
0931-041X(1993)7:6<834:AEIRO->2.0.ZU;2-L
Abstract
Angiotensin converting enzyme (ACE) has multiple effects both as the e nzyme which cleaves angiotensin II from angiotensin I and as that whic h breaks down bradykinin. The present study examines ACE mRNA and prot ein expression in the rat kidney during development. Changes in distri bution and expression during development are consistent with suggestio ns that the renin angiotensin system is important in growth modulation , vascular development and regulation, and protein reabsorption.