CHARACTERIZATION OF BETA-CYCLODEXTRIN FOR DIRECT COMPRESSION TABLETING

A physically modified beta-cyclodextrin (BCD-DC) sample was characteri zed for direct compression tableting. The compactibility of BCD-DC was compared to a commercial beta-cyclodextrin product (Kleptose(R)) and other commonly used direct compression fillers. Heckel analysis and me rcury porosimetry were used to elucidate the primary deformation mecha nism of both beta-cyclodextrin (BCD) samples. BCD-DC showed superior c ompactibility compared to Kleptose(R) and excellent dilution potential . Compactibility and dilution potential of BCD-DC were comparable to m icrocrystalline cellulose. Lubricant sensitivity of BCD-DC was similar to that of microcrystalline cellulose. Tablet strength was found to i ncrease with decrease in particle size. Heckel analysis and mercury po rosimetry revealed that BCD-DC and Kleptose(R) deform primarily by pla stic flow but failed to distinguish between the two samples. Scanning electron photomicrographs and surface area data show that BCD-DC has m ore irregular and laminated particles than Kleptose(R). These differen ces in the external particle characteristics rather than internal crys tal structure are primarily responsible for the greater compactibility of BCD-DC.