POLYDACTYLY, CAMPOMELIA, AMBIGUOUS GENITALIA, CYSTIC DYSPLASTIC KIDNEYS, AND CEREBRAL MALFORMATION IN A FETUS OF CONSANGUINEOUS PARENTS - ANEW MULTIPLE MALFORMATION SYNDROME, OR A SEVERE FORM OF ORAL-FACIAL-DIGITAL SYNDROME TYPE-IV

We describe a 27-week fetus with occipitoschisis, polydactyly, campome lia, cleft palate, laryngeal dysplasia, ocular colobomata, hepatic fib rosis and intrahepatic cyst, ambiguous genitalia, cystic dysplastic ki dneys, and brain malformation. This pattern of abnormalities appears u nique. The differential diagnosis is discussed. The parents are first cousins, making autosomal recessive inheritance likely. (C) 1994 Wiley -Liss, Inc.