Among 14 elderly patients (mean age=74.6 years) with first-episode man
ia who were followed for 3 to 10 years, melt had a higher risk of mort
ality. Compared to 36 elderly patients with multiple episodes of mania
, patients with first-episode mania were twice as likely to have a com
orbid neurological disorder (71% [N=10] versus 28% [N=10]). Mania in t
he elderly appears to be a heterogeneous disorder.