QUANTITATIVE IN-VIVO IONTOPHORETIC STUDIES

An experimental methodology was developed to evaluate the physicochemi cal basis for in vitro-in vivo correlations in iontophoretic delivery situations. This experimental methodology can be used to quantitativel y evaluate the extent of interaction between chemical permeation enhan cers and iontophoresis for drug delivery. The inherent advantages of u sing Ag/AgCl electrodes are fully exploited to control pH and minimize depletion of permeant during prolonged periods of iontophoresis.