B. Geny et al., SAFETY AND EFFICACY OF A NEW TRANSPULMONARY ECHO CONTRAST AGENT IN ECHOCARDIOGRAPHIC STUDIES IN PATIENTS, Journal of the American College of Cardiology, 22(4), 1993, pp. 1193-1198
Objectives. This study was designed to investigate in patients the eff
ect of a new transpulmonary echo contrast agent, made from 5% human se
rum albumin (Albunex), on systemic and pulmonary hemodynamics and the
influence of the contrast doses on left ventricular opacification. Bac
kground. New intravenous transpulmonary echo contrast agents are promi
sing, allowing contrast stress echocardiography and myocardial contras
t echocardiography. Nevertheless, some shortcomings still remain. Thus
, the pulmonary hypertension observed in pigs after Albunex injection
should be investigated in humans, and the optimal dose of contrast age
nt remains to be determined because previous experiments indicated tha
t the left ventricular opacification and attenuation are dose dependen
t. Methods. Albunex in doses of 0.08 and 0.22 ml/kg was successively i
njected intravenously in 20 catheterized patients; in 11 of them, anti
-inflammatory drugs were withdrawn to avoid the blocking of an eventua
l thromboxane-mediated pulmonary artery hypertension. Systemic blood p
ressure and pulmonary artery, capillary wedge and right atrial pressur
es were continuously monitored. Cardiac output, left ventricular fract
ional shortening and blood gases were determined 5 min before and 5 an
d 10 min after each injection. The left ventricular opacification was
qualitatively assessed by three independent observers using a grading
scale from 0 to 3, with 0 indicating an absence of contrast effect and
3 indicating full opacification. Results. No clinical, hemodynamic or
respiratory adverse reactions were observed in any patient. Irrespect
ive of doses, a left ventricular opacification grade greater-than-or-e
qual-to 2 was observed in 74% of the 35 injections that could be evalu
ated. This percentage increased to 94% when the higher dose group was
considered alone. Conclusions. This first report of the effect of Albu
nex injected intravenously on pulmonary artery pressures in humans dem
onstrates that this contrast agent appears to be safe. The significant
left ventricular opacification obtained in a majority of patients wit
hout an important increase in attenuation supports the use of the high
er dose of the contrast agent.