Forest herbicide experiments are increasingly being designed to evalua
te smaller treatment differences when comparing existing effective tre
atments, tank mix ratios, surfactants, and new low-rate products. The
ability to detect small differences in efficacy is dependent upon the
relationship among sample size, type I and II error probabilities, and
the coefficients of variation of the efficacy data. The common source
s of variation in efficacy measurements and design considerations for
controlling variation are reviewed, while current shortcomings are cla
rified. A summary of selected trials estimates that coefficients of va
riation often range between 25 and 100%, making the number of observat
ions necessary to detect small differences very large, especially when
the power of the test (1 - beta) is considered. Very often the power
of the test has been ignored when designing experiments because of the
difficulty in calculating beta. An available program for microcompute
rs is introduced that allows researchers to examine relationships amon
g sample size, effect size, and coefficients of variation for specifie
d designs, alpha and beta. This program should aid investigators in pl
anning studies that optimize experimental power to detect anticipated
effect sizes within resource constraints.