FRUCTOSE-1,6-BISPHOSPHATE FAILS TO AMELIORATE DELAYED NEURONAL DEATH IN THE CA1 AREA AFTER TRANSIENT FOREBRAIN ISCHEMIA IN GERBILS

Fructose-1,6-bisphosphate has been shown to reduce ischaemic-induced b rain damage in rabbits and gerbils. In view of these findings, we inve stigated the effects of fructose-1,6-bisphosphate on delayed neuronal death, following bilateral forebrain ischaemia, in the gerbil hippocam pus at the fourth day of reperfusion. We subjected gerbils to bilatera l forebrain ischaemia for 20 min. Fructose-l,6-bisphosphate was admini stered: intraperitoneally at a dose of 1 g/kg iii saline 1 hr before t he occlusion or at a dose of 1 g/kg 1 hr before the occlusion and ever y 24 hr for 3 days; or intraventricularly at a dose of 0.1 g/kg just a fter the carotid occlusion. No significant differences in the number o f dying cells in the CAI area were found between each group of treated animals when compared with controls. This study suggests that fructos e-1,6-bisphosphate, administered according to these three different sc hedules, fails to ameliorate delayed neuronal death after 20 min of bi lateral forebrain ischaemia in the CAI area of the gerbil hippocampus.