ASSESSMENT OF BRAIN MUSCARINIC ACETYLCHOLINERGIC RECEPTORS IN LIVING MICE USING A SIMPLE PROBE, [I-125] 4-IODODEXETIMIDE AND [I-125] 4-IODOLEVETIMIDE

Authors
SASAKI M MULLERGARTNER HW LEVER JR RAVERT HT DANNALS RF GUILARTE TR WAGNER HN
Citation
M. Sasaki et al., ASSESSMENT OF BRAIN MUSCARINIC ACETYLCHOLINERGIC RECEPTORS IN LIVING MICE USING A SIMPLE PROBE, [I-125] 4-IODODEXETIMIDE AND [I-125] 4-IODOLEVETIMIDE, Neuropharmacology, 32(12), 1993, pp. 1441-1443
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
32
Issue
12
Year of publication
1993
Pages
1441 - 1443
Database
ISI
SICI code
0028-3908(1993)32:12<1441:AOBMAR>2.0.ZU;2-A
Abstract
This study describes assessment of brain muscarinic acetylcholinergic receptors in living mice using a single-crystal radiation detection sy stem, the high-affinity antagonist [I-125]-4-iododexetimide, and the i nactive enantiomer [I-125]-4-iodolevetimide. Kinetics of radioligand b inding, as well as perturbation by atropine displacement, can be deter mined using this simple probe technique.