A. Nagyova et al., EFFECT OF CADMIUM ON HEPATIC-MICROSOMAL MONOOXYGENASE ACTIVITIES IN GUINEA-PIGS WITH LOW AND HIGH ASCORBIC-ACID INTAKE, Journal of nutritional biochemistry, 5(1), 1994, pp. 10-14
The influence of in vivo administration of cadmium on hepatic microsom
al cytochrome P-450 and cytochrome b(5) content, aniline hydroxylase,
p-nitroanisole O-demethylase, and NADPH-cytochrome c reductase activit
ies was investigated in guinea pigs with low (2 mg/animal/day) and hig
h (100 mg/animal/day) ascorbic acid intake. Male guinea pigs received
10 mg Cd/L drinking water for 5 and 12 weeks. Cadmium administration r
esulted in significant decreases in cytochrome P-450 content and NADPH
-cytochrome c reductase activity in the group of guinea pigs with low
ascorbic acid intake, while the decreases were less evident in guineap
igs with high ascorbic acid intake. The activities of aniline hydroxyl
ase and O-demethylase were not apparently changed by Cd administration
, except for the group of guinea pigs with high ascorbic acid intake i
n 12th week of cadmium treatment, when increased activities were obser
ved. These findings suggest that hepatotoxic effect of cadmium manifes
ted by inhibition of hepatic microsomal metabolism may be in part bene
ficially moderated by enhanced ascorbic acid intake.