ANTIBACTERIAL, ANTIFUNGAL AND ANTHELMINTIC ACTIVITIES OF ROOT BARKS OF UVARIA-HOOKERI AND UVARIA-NARUM

On a pharmacological screening, substantial antibacterial, antifungal and anthelmintic activities were observed for the hexane and ethyl ace tate extracts of the root barks of Uvaria narum Wall. and Uvaria hooke ri King. Chromatographic fractionation of these extracts led to the is olation of the triterpenes glutinol, glutinone, taraxerol, P-sitostero l and Annonaceous acetogenins uvariamicins-I, II and III mixture, isod esacetyluvaricin, squamocin-28-one, narumicins-I and II stereoisomeric mixture, squamocin and panalicin. The acetogenins exhibited antimicro bial and anthelmintic activities in their individual screening compara ble with standard drugs and hence their presence could be attributed t o a great extent for the biocidal properties of U. narum and U. hooker i extracts.