PROTECTIVE EFFECT OF HACHIMI-JIO-GAN, AN ORIENTAL HERBAL MEDICINAL MIXTURE, AGAINST CEREBRAL ANOXIA

The protective effect of Hachimi-jio-gan (HJ) against cerebral anoxia was investigated with various experimental models in mice. Minimal eff ective dose of HJ which significantly prolonged the survival time was 0.5 g/kg, p.o. for normobaric hypoxia and 0.5 g/kg, p.o. for KCN- (4 m g/kg, i.v.) induced anoxia. HJ reduced the duration of coma induced by a sublethal dose of KCN (1.8 mg/kg, i.v.) in a dose-dependent manner. Furthermore HJ potentiated the anti-anoxic effect of physostigmine an d the effect of HJ was diminished by the treatment with atropine.