SHORT-TERM EFFECTS OF SOMATOSTATIN ANALOG (SMS 201-995) ON LEFT-VENTRICULAR FUNCTION IN HEALTHY-PERSONS - A SCINTIGRAPHIC STUDY

Since somatostatin has been reported to have a negative inotropic and chronotropic effect on atria and positive inotropic effect on ventricl e, present study was designed to investigate the acute effects of soma tostatin analogue SMS 201-995 infusion on the left ventricular functio n in healthy volunteers. After labeling the autologous red blood cells with 750-1000 MBq 99mTc-perthecnetate, ECG-gated radionuclide ventric ulography was performed. Using Fourier analysis of the left ventricula r time-activity curve, ejection fraction (EF), peak ejection rate (PER ), peak filling rate (PFR), time to endsystole (TES) and normalized TE S/T values were calculated. Study group consisted of 12 healthy volunt eers. Somatostatin analogue SMS 201-995 infusion was given at a rate o f 100 mug/h during 2h. Baseline, 1 st, 2nd h and 4th h imagings were d one using the same protocol. Simultaneously heart rate and blood press ure were recorded. The difference between parameters was tested using Kruskall-Wallis test. The mean heart rate, systolic and diastolic bloo d pressures and did not show any statistically significant change duri ng the somatostatin analogue infusion and 2h later in comparison to ba seline values. The mean PER and PFR had a slight decrease at the first hour of infusion, but the change was not significant. However, the si gnificant correlation of PER values with heart rate, EF and TES observ ed at baseline study were disappeared during the infusion. These resul ts indicate that somatostatin analogue infusion does not appear to cha nge the left ventricular systolic and diastolic function in healthy pe rsons significantly.