EXTRACORPOREAL LIFE-SUPPORT FOR THE TREATMENT OF VIRAL PNEUMONIA - COLLECTIVE EXPERIENCE FROM THE ELSO REGISTRY

Viral pneumonia is the most common indication for pediatric extracorpo real life support (ECLS). Despite this fact, no previous studies have directly stratified patient outcome according to viral etiology. Metho ds: Using the Extracorporeal Life Support Organization (ELSO) registry database, the authors reviewed the national experience of patients un dergoing ECLS with culture or serologically demonstrated viral pneumon ia and compared outcome parameters according to viral etiology. Result s: Patients differed with respect to age and weight according to the v iral type. Patients with respiratory syncytial virus (RSV, median age 3 months), herpes simplex virus (HSV, 0.13 months), cytomegalovirus (C MV, 2.5 months), and adenovirus (0.6 months) were younger than those w ith other viruses (5.5 months). The patient groups did not significant ly differ with respect to pre-ECLS Pao(2) mean airway pressure (MAP), oxygenation index (01), mode, or duration of ECLS. The overall surviva l of patients with viral pneumonia was 57% although patients with RSV or CMV were found to have a 67% survival. Patients infected with HSV a nd adenovirus had a significantly lower survival rate (31% and 25%, re spectively) when compared with those with RSV. In addition RSV pneumon ia was associated with fewer cardiovascular complications than several of the other viral types. When comparison was made between survivors and nonsurvivors, a higher last pre-ECLS MAP and increased incidence o f elevated creatinine and renal failure requiring dialysis were noted among nonsurvivors. Conclusion: ECLS remains an important modality in the treatment of neonatal and pediatric patients with respiratory fail ure secondary to viral pneumonia. The survival rate of these patients varies according to the type of viral infection. Copyright (C) 1997 by W.B. Saunders Company.