ORGAN CHANGES AFTER INTRAVENOUS TRINONANOIN ADMINISTRATION IN RABBITS

For 11 days, an odd-numbered medium-chain triglyceride (trinonanoin, C (9)TG)/long-chain triglyceride (LCT) emulsion was given parenterally t o rabbits, providing 46.5 % of total energy. In comparison with LCT or MCT/LCT fat emulsions, no negative effects on organ weights and liver lipid concentrations were noted. In some rabbits of the C(9)TG/LCT gr oup macroscopically but not histologically visible liver changes were observed. The extent of nonanoic acid deposition in liver triglyceride s, liver phospholipids, adipose tissue and skeletal muscle after C(9)T G/LCT administration was similar to C-8/C-10 deposition in the MCT/LCT group; the enrichment of adipose tissue with 16 mol% was higher than expected.