INTESTINAL FAT DIGESTION PLAYS A SIGNIFICANT ROLE IN FAT-INDUCED SUPPRESSION OF GASTRIC-ACID SECRETION AND GASTRIN-RELEASE IN THE RAT

We have investigated the role of intestinal fat digestion in fat-induc ed suppression of gastric acid secretion and gastrin release in the ra t. Intraduodenal administration of oleic acid (1O%, pH 6.5) and trigly ceride (10%, pH 6.5) at a rate of 2 ml/hr resulted in significant supp ression of gastric acid secretion and gastrin release stimulated by in tragastric perfusion of peptone (0.5%). Diversion of pancreatic juice from the duodenum completely abolished triglyceride-induced inhibition of peptone-stimulated gastric acid secretion and plasma gastrin relea se, but oleic acid-suppressed gastric acid secretion and gastrin relea se were unaffected by pancreatic juice diversion. Intraduodenal admini stration of digested triglyceride, prepared by preincubation with lipa se, caused significant suppression of the peptone-induced gastric acid secretion and rise in plasma gastrin levels, even though pancreatic j uice was excluded The results of this study indicate that digestive pr oducts of triglyceride by pancreatic juice, especially by lipase, are responsible for the intestinal fat-induced inhibition of gastric acid secretion and gastrin release and that intestinal fat digestion plays a significant role in the mechanism.