CHOLESTEROL ABSORPTION AND EXCRETION IN ILEOSTOMY SUBJECTS ON HIGH-DIETARY-CHOLESTEROL AND LOW-DIETARY-CHOLESTEROL INTAKES

Six healthy ileostomy subjects were given [H-3]cholesterol and [C-14]b eta-sitosterol in a single meal together with two controlled diets con taining 150 or 450 mg cholesterol/d. Each diet was eaten for 3 d. Chol esterol absorption and excretion of cholesterol, bile acids, fat, ener gy, and nitrogen were analyzed. Fractional cholesterol absorption incr eased from 44+/-2.6% (($) over bar x+/-SE) to 61+/-3.4% (P<0.05), but absolute cholesterol absorption decreased from 191+/-11 to 94+/-9 mg/d (P<0.05) on low cholesterol intake compared with high cholesterol int ake. Weight of ileostomy effluent, or excretion of energy, nitrogen, f at, and bile acids did not differ between periods. Endogenous choleste rol excretion remained unchanged whereas net cholesterol excretion (ou tput minus intake) was 37% higher (P<0.05) on low compared with high c holesterol intake.