SENSITIVITY TO RUBOMYCIN AND CYTOLOGICAL CHARACTERISTICS OF MOUSE LEUKEMIA P-388 CELLS - SUGGESTED RELATIONSHIPS

Authors
SHESTOVA OL LITINSKAYA LL DYAGILEVA OA KOTELNIKOV VM POGORELOV VM KOZINETS GI
Citation
Ol. Shestova et al., SENSITIVITY TO RUBOMYCIN AND CYTOLOGICAL CHARACTERISTICS OF MOUSE LEUKEMIA P-388 CELLS - SUGGESTED RELATIONSHIPS, Gematologia i transfuziologia, 38(8), 1993, pp. 15-18
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
38
Issue
8
Year of publication
1993
Pages
15 - 18
Database
ISI
SICI code
0234-5730(1993)38:8<15:STRACC>2.0.ZU;2-V
Abstract
In search for markers of tumor cell resistance to cytostatic drugs, cy tological characteristics were compared of resistant and sensitive to rubomycin variants of mouse P-388 leukemia. Morphocytochemical, morpho metrical and cytogenetic investigations were performed as well as meas urements of intracellular pH. As shown by the fluorescent test, pH lev els in rubomycin-sensitive and resistant subpopulations differed. This fact evidences an important role of intracellular pH in inducing the resistance and revealed some mechanisms of rubomycin-resistant tumor c ell selection.