INTRAVENOUS DALARGIN CONTRIBUTION TO AN I NCREASE OF BLOOD REINFUSIONEFFICACY AT LATE STAGES OF HEMORRHAGIC-SHOCK

Acute experiments on 63 adult rabbits have shown that acute divided bl ood loss for 5 min (27+/-1 % of the whole blood volume) results in the development of reversible hemorrhagic shock with survival of all the animals. In the same volume of continuous blood exfusion (27+/-5 % of blood volume) or an increase in blood loss to 43+/-2 % of blood volume hemorrhagic shock proved irreversible. Early reinfusion of heparinize d blood saved all the animals, whereas late reinfusions only prolonged the survival. Intravenous administration of dalargin (0.1 mg/kg) in l ate shock was not effective and all the animals died. Dalargin introdu ction after blood reinfusion in late shock saved the animals lives. Th e conclusion is made on benefits of intravenous dalargin for raising t he efficacy of reinfusions (hemotransfusion) at late stages of severe hemorrhagic shock.