MATERNAL EFFECT AND FAMILIAL AGGREGATION IN NIDDM - THE CODIAB STUDY

Citation
F. Thomas et al., MATERNAL EFFECT AND FAMILIAL AGGREGATION IN NIDDM - THE CODIAB STUDY, Diabetes, 43(1), 1994, pp. 63-67
Citations number
34
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Journal title
ISSN journal
00121797
Volume
43
Issue
1
Year of publication
1994
Pages
63 - 67
Database
ISI
SICI code
0012-1797(1994)43:1<63:MEAFAI>2.0.ZU;2-2
Abstract
Non-insulin-dependent diabetes mellitus (NIDDM) is known to have a str ong genetic basis, but the mode of inheritance is still unknown. Recen t studies have suggested that maternal inheritance is important; this complicates the transmission pattern of NIDDM. In our study, the famil ial aggregation of diabetes and the maternal effect were investigated through three generations. The CODIAB Study recruited 536 NIDDM patien ts between 35 and 74 years of age from 10 diabetes centers in France. Familial aggregation was confirmed: among 218 NIDDM patients, 66% had at least one diabetic relative. Mothers were implicated 2 times more f requently than fathers (P < 0.001). This maternal effect was confirmed because more diabetic cases were noted among maternal than paternal a unts and uncles (P < 0.02). When we considered the next generation, wo men had more diabetic offspring than men (P < 0.01). Other factors sus ceptible to modify the familial aggregation were considered. The mater nal effect was not significantly related to the patients' ages (P > 0. 2). The genetic component was more important when the diagnosis was ma de earlier, but the maternal effect was homogeneous (P > 0.3). In conc lusion, we found a familial aggregation of diabetes that suggests a st rong genetic component with a mode of inheritance that may be influenc ed by a maternal environment.