ADRENIC ACID DELTA-4 DESATURATION AND FATTY-ACID COMPOSITION IN LIVER-MICROSOMES OF SPONTANEOUSLY DIABETIC WISTAR BB RATS

Authors
MIMOUNI V NARCE M HUANG YS HORROBIN DF POISSON JP
Citation
V. Mimouni et al., ADRENIC ACID DELTA-4 DESATURATION AND FATTY-ACID COMPOSITION IN LIVER-MICROSOMES OF SPONTANEOUSLY DIABETIC WISTAR BB RATS, Prostaglandins, leukotrienes and essential fatty acids, 50(1), 1994, pp. 43-47
Citations number
38
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
50
Issue
1
Year of publication
1994
Pages
43 - 47
Database
ISI
SICI code
0952-3278(1994)50:1<43:AADDAF>2.0.ZU;2-6
Abstract
We examined the Delta 4 (n-6) desaturation and the fatty acid composit ion of liver microsomes in the insulin-dependent spontaneously diabeti c Wistar Bio-Breeding (BB) rat. The desaturation of adrenic acid to n- 6 docosapentaenoic acid was decreased in the normo- and hyperglycemic diabetic rats. Insulin treatment with 1.0 IU. 100 g body weight(-1) tw ice a day for 2 days restored the reduced activity during the hypoglyc emic period. The pattern of responses was similar to that of linoleic acid Delta 6 and dihomo-gamma-linolenic acid Delta 5 desaturases, with a non-parallel relationship between the desaturation system and the g lycemia. The microsomal fatty acid composition of BB rat liver reflect ed only partially to the Delta 4 desaturation at different states of g lycemia. Factors other than impaired desaturation system are involved in the fatty acid metabolism of spontaneously diabetic rats.