INFLUENCE OF 3 ALLOPLASTIC MATERIALS ON CALVARIAL BONE HEALING - AN EXPERIMENTAL EVALUATION OF HTR(R)-POLYMER, LACTOMER BEADS, AND A CARRIER GEL

This study evaluated experimentally three alloplastic materials (HTR(R )-polymer, lactomer beads, and a resorbable gel substance). A bioassay performed in a critical size defect rat model disclosed no osteoinduc tive capacity of any material. A total of 72 trephine calvarial 5-mm d efects were created in 18 rabbits. The inlays were tested relative to control (empty) defects in a varied pattern, and the results were asse ssed by light microscopy and contact radiography after 4 and 15 weeks. The HTR-polymer alone or combined with bone chips displayed the most rapid early bone regeneration and more mature bone marrow redevelopmen t. The present form of the gel material seems to be less suitable for use as a carrier substance because of the intense inflammatory respons e produced.