CARDIAC MANIFESTATIONS OF PHOSPHOLIPID AN TIBODY SYNDROME - STUDY OF 2 CASES

Cardiac manifestations of phospholipid antibody syndrome may include m itral and/or aortic valve disease, pseudo-infectious endocarditis, thr ombi of the right atrium, myocardial infection, pulmonary artery hyper tension and cardiomyopathy with global or segmental left ventricular d ysfunction. The authors report two patients showing evidence simultane ously of a circulating anticoagulant, dissociated syphilis serology an d cardiolipin antibodies at a very high level. They had the majority o f cardiac complications described in phospholipid antibody syndrome. B oth also had renal involvement and one of them had recurrent Venous th romboses and a cerebrovascular accident. Prolonged corticosteroid trea tment, combined with anticoagulants in one patient, was accompanied by stability of lesions with follow-up of five years and ten months resp ectively.