Cranial magnetic resonance imaging (MRI) was performed prospectively i
n 45 children (ages 3-27 months) with clinically documented motor dela
y to evaluate the ability of MRI to determine etiologic factors, to de
termine whether myelination correlated with motor delay, and whether t
he clinical category corresponded with the imaging findings. Of the 22
children diagnosed clinically as having major motor delay (i.e., cere
bral palsy), 77% had magnetic resonance imaging abnormalities. In 23%,
etiologic associations were established from MRI alone and in 32% a c
linically suspected etiology was supported. No children had myelinatio
n delay as the sole abnormality. In 23 children with minor motor delay
, only 17% had abnormal scans. Clearly, MRI provided useful informatio
n in the majority of children with cerebral palsy; therefore, a classi
fication system is proposed in which MRI can be used in conjunction wi
th clinical assessment to specify more precisely the etiologic factors
in cerebral palsy.