DEVELOPMENT OF NOVEL BIOSENSOR ENZYME ELECTRODES - GLUCOSE-OXIDASE MULTILAYER ARRAYS IMMOBILIZED ONTO SELF-ASSEMBLED MONOLAYERS ELECTRODES

Amperometric biosensors under development are based on electron transf er communication between enzyme redox sites and electrodes. These requ ire well-organized networks of enzymes exhibiting long-range electron transfer properties. An enzyme electrode is described that consists of glucose oxidase networks organized on a self-assembled monolayer of f unctionalized thiols on gold electrodes. The protein array supports el ectrical communication with the electrode, and the resulting assembly can be used as a glucose biosensor.