The consistency of penicillin allergy documentation in the patient cha
rt, pharmacy profile, and medication administration record was assesse
d, along with the correctness of the self-reported patient history of
penicillin allergy. One hundred fifty adult in-patients with a reporte
d penicillin allergy were interviewed about their allergy. Questions i
ncluded length of time since the allergic reaction, symptoms of the re
action, and whether rechallenge was ever attempted. Patients were clas
sified into categories of (1) more severe allergy, (2) less severe all
ergy, or (3) intolerance on the basis of results of the interview. The
patient pharmacy profile, chart, and medication administration record
were reviewed to determine whether the allergy label was present. Pat
ients who received antimicrobials during their hospitalization were ev
aluated. Of 117 patients, 82.9% were classified as allergic and 17.1%
as intolerant. The allergy was documented in 98.7% of patient charts a
nd 96.7% of medication administration records. The symptoms of the all
ergic reaction were described in the chart for only 34% of patients. A
gents substituted for penicillin were potentially more toxic in 70.4%
of cases, equally effective in all cases, and more costly in 55.5% of
cases. Most, but not all, patients labeled as penicillin allergic had
a history consistent with an allergy to the drug. Pharmacists can help
ensure accurate allergy documentation by evaluating patients and educ
ating both patients and health care professionals.