The stability of foscarnet sodium in 0.9% sodium chloride injection wa
s studied. Foscarnet sodium 24 mg/mL was added to polyvinyl chloride i
.v. bags containing 0.9% sodium chloride injection to give a theoretic
al foscarnet sodium concentration of 12 mg/mL. Ten bags of solution we
re stored at 25-degrees-C in normal laboratory light, 10 bags were sto
red at 25-degrees-C in the dark, and 10 bags were stored at 5-degrees-
C in the dark. Samples were analyzed for foscarnet concentration by hi
gh-performance liquid chromatography on days 0, 3, 8, 10, 15, and 30.
The solutions were visually inspected for particulates, and pH was mea
sured. Foscarnet sodium was stable in all the solutions for up to 30 d
ays under all the storage conditions; mean foscarnet concentrations di
d not decline below 99% of initial values. No particulates appeared, a
nd there were no important changes in pH. Foscarnet sodium 12 mg/mL in
0.9% sodium chloride injection was stable for up to 30 days when stor
ed at 25-degrees-C and exposed to light, 25-degrees-C and protected fr
om light, or 5-degree-C and protected from light.